User: Guest  Login
Document type:
journal article 
Author(s):
Lehmann-Horn, Klaus; Sagan, Sharon A; Winger, Ryan C; Spencer, Collin M; Bernard, Claude C A; Sobel, Raymond A; Zamvil, Scott S 
Title:
CNS accumulation of regulatory B cells is VLA-4-dependent. 
Abstract:
To investigate the role of very late antigen-4 (VLA-4) on regulatory B cells (Breg) in CNS autoimmune disease.Experimental autoimmune encephalomyelitis (EAE) was induced in mice selectively deficient for VLA-4 on B cells (CD19cre/?4(f/f)) by immunization with myelin oligodendrocyte glycoprotein (MOG) peptide (p)35-55 or recombinant human (rh) MOG protein. B-cell and T-cell populations were examined by flow cytometry and immunohistochemistry. Breg were evaluated by intracellular IL-10 staining of...    »
 
Journal title abbreviation:
Neurol Neuroimmunol Neuroinflamm 
Year:
2016 
Journal volume:
Journal issue:
Pages contribution:
e212 
Language:
eng 
Print-ISSN:
2332-7812 
TUM Institution:
Neurologische Klinik und Poliklinik