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Document type:
journal article 
Author(s):
Vercruysse, Pauline; Sinniger, Jérôme; El Oussini, Hajer; Scekic-Zahirovic, Jelena; Dieterlé, Stéphane; Dengler, Reinhard; Meyer, Thomas; Zierz, Stephan; Kassubek, Jan; Fischer, Wilhelm; Dreyhaupt, Jens; Grehl, Torsten; Hermann, Andreas; Grosskreutz, Julian; Witting, Anke; Van Den Bosch, Ludo; Spreux-Varoquaux, Odile; GERP ALS Study Group; Ludolph, Albert C; Dupuis, Luc; Borisow, Nadja; Holm, Theresa; Maier, Andre; Meyer, Thomas; Budde, Paula; Grehl, Torsten; Gruhn, Kai; Bewersdorff, Malte; Hene...    »
 
Title:
Alterations in the hypothalamic melanocortin pathway in amyotrophic lateral sclerosis. 
Abstract:
Amyotrophic lateral sclerosis, the most common adult-onset motor neuron disease, leads to death within 3 to 5 years after onset. Beyond progressive motor impairment, patients with amyotrophic lateral sclerosis suffer from major defects in energy metabolism, such as weight loss, which are well correlated with survival. Indeed, nutritional intervention targeting weight loss might improve survival of patients. However, the neural mechanisms underlying metabolic impairment in patients with amyotroph...    »
 
Journal title abbreviation:
Brain 
Year:
2016 
Journal volume:
139 
Journal issue:
Pt 4 
Pages contribution:
1106-22 
Language:
eng 
Print-ISSN:
0006-8950 
TUM Institution:
Neurologische Klinik und Poliklinik