User: Guest  Login
Document type:
journal article 
Author(s):
Lech, Maciej; Lorenz, Georg; Kulkarni, Onkar P; Grosser, Marian O O; Stigrot, Nora; Darisipudi, Murthy N; Günthner, Roman; Wintergerst, Maximilian W M; Anz, David; Susanti, Heni Eka; Anders, Hans-Joachim 
Title:
NLRP3 and ASC suppress lupus-like autoimmunity by driving the immunosuppressive effects of TGF-? receptor signalling. 
Abstract:
The NLRP3/ASC inflammasome drives host defence and autoinflammatory disorders by activating caspase-1 to trigger the secretion of mature interleukin (IL)-1?/IL-18, but its potential role in autoimmunity is speculative.We generated and phenotyped Nlrp3-deficient, Asc-deficient, Il-1r-deficient and Il-18-deficient C57BL/6-lpr/lpr mice, the latter being a mild model of spontaneous lupus-like autoimmunity.While lack of IL-1R or IL-18 did not affect the C57BL/6-lpr/lpr phenotype, lack of NLRP3 or ASC...    »
 
Journal title abbreviation:
Ann Rheum Dis 
Year:
2015 
Journal volume:
74 
Journal issue:
12 
Pages contribution:
2224-35 
Language:
eng 
Print-ISSN:
0003-4967 
TUM Institution:
Abteilung für Nephrologie