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Document type:
journal article 
Author(s):
Koellisch, Ulrich; Gringeri, Concetta V; Rancan, Giaime; Farell, Eliane V; Menzel, Marion I; Haase, Axel; Schwaiger, Markus; Schulte, Rolf F 
Title:
Metabolic imaging of hyperpolarized [1-(13) C]acetate and [1-(13) C]acetylcarnitine - investigation of the influence of dobutamine induced stress. 
Abstract:
The metabolism of acetate in the heart resembles fatty acid metabolism, which is altered in several diseases like ischemia, diabetes mellitus, and heart failure. A signal-to-noise ratio (SNR) optimized imaging framework for in vivo measurements of hyperpolarized [1-(13) C]acetate and its metabolic product [1-(13) C]acetylcarnitine (ALCAR) in rats at 3 Tesla (T) is presented in this work.A spectrospatial pulse was combined with IDEAL encoding to acquire well separated metabolic maps. The influenc...    »
 
Journal title abbreviation:
Magn Reson Med 
Year:
2015 
Journal volume:
74 
Journal issue:
Pages contribution:
1011-8 
Language:
eng 
Print-ISSN:
0740-3194 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik