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Document type:
journal article 
Author(s):
van Soom, J; Crucitti, GC; Gladysz, R; van der Veken, P; Di Santo, R; Stuyver, I; Buck, V; Lambeir, AM; Magdolen, V; Joossens, J; Augustyns, K 
Title:
The first potent diphenyl phosphonate KLK4 inhibitors with unexpected binding kinetics 
Abstract:
KLK4 is a serine protease from the kallikrein family that is involved in cancer progression. The diphenyl phosphonate warhead is intended to bind irreversibly with serine proteases, but unexpectedly, very potent KLK4 diphenyl phosphonate inhibitors were discovered with reversible inhibition kinetics. 
Journal title abbreviation:
MedChemComm 
Year:
2015 
Journal volume:
Journal issue:
11 
Pages contribution:
1954-1958 
Language:
eng 
Print-ISSN:
2040-2503 
TUM Institution:
Frauenklinik und Poliklinik