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Document type:
Journal Article; 4 
Author(s):
Kong, Bo; Wu, Weiwei; Cheng, Tao; Schlitter, Anna Melissa; Qian, Chengjia; Bruns, Philipp; Jian, Ziying; Jäger, Carsten; Regel, Ivonne; Raulefs, Susanne; Behler, Nora; Irmler, Martin; Beckers, Johannes; Friess, Helmut; Erkan, Mert; Siveke, Jens T; Tannapfel, Andrea; Hahn, Stephan A; Theis, Fabian J; Esposito, Irene; Kleeff, Jörg; Michalski, Christoph W 
Title:
A subset of metastatic pancreatic ductal adenocarcinomas depends quantitatively on oncogenic Kras/Mek/Erk-induced hyperactive mTOR signalling. 
Abstract:
Oncogenic Kras-activated robust Mek/Erk signals phosphorylate to the tuberous sclerosis complex (Tsc) and deactivates mammalian target of rapamycin (mTOR) suppression in pancreatic ductal adenocarcinoma (PDAC); however, Mek and mTOR inhibitors alone have demonstrated minimal clinical antitumor activity.We generated transgenic mouse models in which mTOR was hyperactivated either through the Kras/Mek/Erk cascade, by loss of Pten or through Tsc1 haploinsufficiency. Primary cancer cells were isolat...    »
 
Journal title abbreviation:
Gut 
Year:
2016 
Journal volume:
65 
Journal issue:
Pages contribution:
647-57 
Language:
eng 
Print-ISSN:
0017-5749 
TUM Institution:
Chirurgische Klinik und Poliklinik; II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Allgemeine Pathologie und Pathologische Anatomie