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Document type:
journal article 
Author(s):
Seidensaal, Katharina; Nollert, Andre; Feige, Agnes Hiou; Muller, Marie; Fleming, Thomas; Gunkel, Nikolas; Zaoui, Karim; Grabe, Niels; Weichert, Wilko; Weber, Klaus-Josef; Plinkert, Peter; Simon, Christian; Hess, Jochen 
Title:
Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma. 
Abstract:
An inverse correlation between expression of the aldehyde dehydrogenase 1 subfamily A2 (ALDH1A2) and gene promoter methylation has been identified as a common feature of oropharyngeal squamous cell carcinoma (OPSCC). Moreover, low ALDH1A2 expression was associated with an unfavorable prognosis of OPSCC patients, however the causal link between reduced ALDH1A2 function and treatment failure has not been addressed so far.Serial sections from tissue microarrays of patients with primary OPSCC (n = 1...    »
 
Journal title abbreviation:
Mol Cancer 
Year:
2015 
Journal volume:
14 
Journal issue:
Pages contribution:
204 
Language:
eng 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie