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Document type:
journal article 
Author(s):
Beck, Philipp; Cui, Haissi; Hegemann, Julian D; Marahiel, Mohammed A; Krüger, Achim; Groll, Michael 
Title:
Targeted Delivery of Proteasome Inhibitors to Somatostatin-Receptor-Expressing Cancer Cells by Octreotide Conjugation. 
Abstract:
Clinical application of proteasome inhibitors (PIs) is so far limited to peripheral blood cancers due to the pronounced cytotoxicity towards all cell types. Targeted delivery of PIs could permit the treatment of other cancers along with decreasing side effects. Herein we describe the first small-molecule proteasome inhibitor conjugate for targeted delivery, created by fusing PIs to a synthetic ligand of somatostatin receptors, which are highly expressed in a variety of tumors. X-ray crystallogra...    »
 
Journal title abbreviation:
ChemMedChem 
Year:
2015 
Journal volume:
10 
Journal issue:
12 
Pages contribution:
1969-73 
Language:
eng 
Print-ISSN:
1860-7179 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung