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Document type:
journal article 
Author(s):
Hoffmann, Franziska S; Hofereiter, Johann; Rübsamen, Heike; Melms, Johannes; Schwarz, Sigrid; Faber, Hans; Weber, Peter; Pütz, Benno; Loleit, Verena; Weber, Frank; Hohlfeld, Reinhard; Meinl, Edgar; Krumbholz, Markus 
Title:
Fingolimod induces neuroprotective factors in human astrocytes. 
Abstract:
Fingolimod (FTY720) is the first sphingosine-1-phosphate (S1P) receptor modulator approved for the treatment of multiple sclerosis. The phosphorylated active metabolite FTY720-phosphate (FTY-P) interferes with lymphocyte trafficking. In addition, it accumulates in the CNS and reduces brain atrophy in multiple sclerosis (MS), and neuroprotective effects are hypothesized.Human primary astrocytes as well as human astrocytoma cells were stimulated with FTY-P or S1P. We analyzed gene expression by a...    »
 
Journal title abbreviation:
J Neuroinflammation 
Year:
2015 
Journal volume:
12 
Pages contribution:
184 
Language:
eng 
TUM Institution:
Neurologische Klinik und Poliklinik