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Document type:
journal article 
Author(s):
Bennett, JeffreyL; OConnor, KevinC; Bar-Or, Amit; Zamvil, ScottS; Hemmer, Bernhard; Tedder, ThomasF; von Budingen, H-Christia; Stuve, Olaf; Yeaman, MichaelR; Smith, TerryJ; Stadelmann, Christine 
Title:
B lymphocytes in neuromyelitis optica. 
Abstract:
Neuromyelitis optica (NMO) is an inflammatory autoimmune disorder of the CNS that predominantly affects the spinal cord and optic nerves. A majority (approximately 75%) of patients with NMO are seropositive for autoantibodies against the astrocyte water channel aquaporin-4 (AQP4). These autoantibodies are predominantly IgG1, and considerable evidence supports their pathogenicity, presumably by binding to AQP4 on CNS astrocytes, resulting in astrocyte injury and inflammation. Convergent clinical...    »
 
Journal title abbreviation:
Neurol Neuroimmunol Neuroinflamm 
Year:
2015 
Journal volume:
Journal issue:
Pages contribution:
Language:
eng 
Print-ISSN:
2332-7812 
TUM Institution:
Neurologische Klinik und Poliklinik