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Document type:
journal article 
Author(s):
Jost, Petr; Svobodova, Hana; Stetina, Rudolf 
Title:
Induction and repair of DNA cross-links induced by sulfur mustard in the A-549 cell line followed by a comet assay. 
Abstract:
Sulfur mustard is a highly toxic chemical warfare agent with devastating impact on intoxicated tissues. DNA cross-links are probably the most toxic DNA lesions induced in the cell by sulfur mustard. The comet assay is a very sensitive method for measuring DNA damage. In the present study using the A-549 lung cell line, the comet assay protocol was optimized for indirect detection of DNA cross-links induced by sulfur mustard. The method is based on the additional treatment of the assayed cells co...    »
 
Journal title abbreviation:
Chem Biol Interact 
Year:
2015 
Journal volume:
237 
Pages contribution:
31-7 
Language:
eng 
Print-ISSN:
0009-2797 
TUM Institution:
III. Medizinische Klinik und Poliklinik