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Document type:
journal article 
Author(s):
Hoffmann, Thomas; Krackhardt, Angela M; Antes, Iris 
Title:
Quantitative Analysis of the Association Angle between T-cell Receptor V?/V? Domains Reveals Important Features for Epitope Recognition. 
Abstract:
T-cell receptors (TCR) play an important role in the adaptive immune system as they recognize pathogen- or cancer-based epitopes and thus initiate the cell-mediated immune response. Therefore there exists a growing interest in the optimization of TCRs for medical purposes like adoptive T-cell therapy. However, the molecular mechanisms behind T-cell signaling are still predominantly unknown. For small sets of TCRs it was observed that the angle between their V?- and V?-domains, which bind the epi...    »
 
Journal title abbreviation:
PLoS Comput Biol 
Year:
2015 
Journal volume:
11 
Journal issue:
Pages contribution:
e1004244 
Language:
eng 
Print-ISSN:
1553-734X 
TUM Institution:
III. Medizinische Klinik und Poliklinik