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Document type:
journal article 
Author(s):
Murakawa, Yasuhiro; Hinz, Michael; Mothes, Janina; Schuetz, Anja; Uhl, Michael; Wyler, Emanuel; Yasuda, Tomoharu; Mastrobuoni, Guido; Friedel, Caroline C; Dölken, Lars; Kempa, Stefan; Schmidt-Supprian, Marc; Blüthgen, Nils; Backofen, Rolf; Heinemann, Udo; Wolf, Jana; Scheidereit, Claus; Landthaler, Markus 
Title:
RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-?B pathway. 
Abstract:
The RNA-binding protein RC3H1 (also known as ROQUIN) promotes TNF? mRNA decay via a 3'UTR constitutive decay element (CDE). Here we applied PAR-CLIP to human RC3H1 to identify ~ 3,800 mRNA targets with>16,000 binding sites. A large number of sites are distinct from the consensus CDE and revealed a structure-sequence motif with U-rich sequences embedded in hairpins. RC3H1 binds preferentially short-lived and DNA damage-induced mRNAs, indicating a role of this RNA-binding protein in the post-trans...    »
 
Journal title abbreviation:
Nat Commun 
Year:
2015 
Journal volume:
Pages contribution:
7367 
Language:
eng 
TUM Institution:
III. Medizinische Klinik und Poliklinik