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Document type:
Zeitschriftenaufsatz 
Author(s):
Gruijthuijsen, Y. K.; Grieshuber, I.; Stöcklinger, A.; Tischler, U.; Fehrenbach, T.; Weller, M. G.; Vogel, L.; Vieths, S.; Pöschl, U.; Duschl, A. 
Title:
Nitration Enhances the Allergenic Potential of Proteins 
Abstract:
Background: Recent investigations have shown that proteins, including Bet v 1a, are nitrated by exposure to polluted urban air. We have investigated immunogenic and allergenic properties of in vitro nitrated allergens in in vivo models. Methods: Untreated and nitrated samples of ovalbumin or Bet v 1a were compared for their ability to stimulate proliferation and cytokine secretion in splenocytes from DO11.10 or from sensitized BALB/c mice, and for their ability to induce specific immunoglobulin...    »
 
Keywords:
Air pollution; Bet v 1; Epitopes; Immunoglobulin E; Nitration; Nitrotyrosine; Ovalbumin 
Journal title:
International Archives of Allergy and Immunology 
Year:
2006 
Journal volume:
141 
Journal issue:
Pages contribution:
265--275 
Fulltext / DOI:
Publisher:
S. Karger AG 
Publisher address:
Basel, Switzerland 
Print-ISSN:
1423-0097 
E-ISSN:
1423-0097 
Notes:
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.