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Document type:
journal article 
Author(s):
Eichenmüller, Melanie; Trippel, Franziska; Kreuder, Michaela; Beck, Alexander; Schwarzmayr, Thomas; Häberle, Beate; Cairo, Stefano; Leuschner, Ivo; von Schweinitz, Dietrich; Strom, Tim M; Kappler, Roland 
Title:
The genomic landscape of hepatoblastoma and their progenies with HCC-like features. 
Abstract:
Hepatoblastoma (HB) is the most common childhood liver cancer and occasionally presents with histological and clinical features reminiscent of hepatocellular carcinoma (HCC). Identification of molecular mechanisms that drive the neoplastic continuation towards more aggressive HCC phenotypes may help to guide the new stage of targeted therapies.We performed comprehensive studies on genetic and chromosomal alterations as well as candidate gene function and their clinical relevance.Whole-exome sequ...    »
 
Journal title abbreviation:
J Hepatol 
Year:
2014 
Journal volume:
61 
Journal issue:
Pages contribution:
1312-20 
Language:
eng 
Print-ISSN:
0168-8278 
TUM Institution:
Institut für Humangenetik