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Dokumenttyp:
journal article 
Autor(en):
Tilstam, Pathricia V; Gijbels, Marion J; Habbeddine, Mohamed; Cudejko, Céline; Asare, Yaw; Theelen, Wendy; Zhou, Baixue; Döring, Yvonne; Drechsler, Maik; Pawig, Lukas; Simsekyilmaz, Sakine; Koenen, Rory R; de Winther, Menno P J; Lawrence, Toby; Bernhagen, Jürgen; Zernecke, Alma; Weber, Christian; Noels, Heidi 
Titel:
Bone marrow-specific knock-in of a non-activatable Ikk? kinase mutant influences haematopoiesis but not atherosclerosis in Apoe-deficient mice. 
Abstract:
The Ikk? kinase, a subunit of the NF-?B-activating IKK complex, has emerged as an important regulator of inflammatory gene expression. However, the role of Ikk?-mediated phosphorylation in haematopoiesis and atherogenesis remains unexplored. In this study, we investigated the effect of a bone marrow (BM)-specific activation-resistant Ikk? mutant knock-in on haematopoiesis and atherosclerosis in mice.Apolipoprotein E (Apoe)-deficient mice were transplanted with BM carrying an activation-resistant...    »
 
Zeitschriftentitel:
PLoS ONE 
Jahr:
2014 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
e87452 
Sprache:
eng 
TUM Einrichtung:
Klinik für Gefäßchirurgie