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Document type:
journal article 
Author(s):
Beuke, Katharina; Schildberg, Frank A; Pinna, Federico; Albrecht, Ute; Liebe, Roman; Bissinger, Michaela; Schirmacher, Peter; Dooley, Steven; Bode, Johannes G; Knolle, Percy A; Kummer, Ursula; Breuhahn, Kai; Sahle, Sven 
Title:
Quantitative and integrative analysis of paracrine hepatocyte activation by nonparenchymal cells upon lipopolysaccharide induction. 
Abstract:
Gut-derived bacterial lipopolysaccharides (LPS) stimulate the secretion of tumour necrosis factor (TNF) from liver macrophages (MCs), liver sinusoidal endothelial cells (LSECs) and hepatic stellate cells (HSCs), which control the acute phase response in hepatocytes through activation of the NF-?B pathway. The individual and cooperative impact of nonparenchymal cells on this clinically relevant response has not been analysed in detail due to technical limitations. To gain an integrative view on t...    »
 
Journal title abbreviation:
FEBS J 
Year:
2017 
Journal volume:
284 
Journal issue:
Pages contribution:
796-813 
Language:
eng 
Print-ISSN:
1742-464X 
TUM Institution:
Institut für Molekulare Immunologie