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Document type:
journal article 
Author(s):
Wittlich, Michaela; Dudek, Michael; Böttcher, Jan P; Schanz, Oliver; Hegenbarth, Silke; Bopp, Tobias; Schmitt, Edgar; Kurts, Christian; Garbers, Christoph; Rose John, Stefan; Knolle, Percy A; Wohlleber, Dirk 
Title:
Liver sinusoidal endothelial cell cross-priming is supported by CD4 T cell-derived IL-2. 
Abstract:
Liver sinusoidal endothelial cells (LSECs) are prominent liver-resident antigen (cross-)presenting cells. LSEC cross-priming of naïve CD8 T cells does not require CD4 T cell help in contrast to priming by dendritic cells (DC) but leads to the formation of memory T cells that is preceded by transient Granzyme B (GzmB) expression. Here we provide evidence for a so far unrecognized CD4 T helper cell function in LSEC-induced CD8 T cell activation.Naïve CD8 T cells and differentiated T helper 1 (T1)...    »
 
Journal title abbreviation:
J Hepatol 
Year:
2017 
Journal volume:
66 
Journal issue:
Pages contribution:
978-986 
Language:
eng 
Print-ISSN:
0168-8278 
TUM Institution:
Institut für Molekulare Immunologie