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Document type:
journal article 
Author(s):
Wieland, Dominik; Kemming, Janine; Schuch, Anita; Emmerich, Florian; Knolle, Percy; Neumann-Haefelin, Christoph; Held, Werner; Zehn, Dietmar; Hofmann, Maike; Thimme, Robert 
Title:
TCF1 hepatitis C virus-specific CD8 T cells are maintained after cessation of chronic antigen stimulation. 
Abstract:
Differentiation and fate of virus-specific CD8 T cells after cessation of chronic antigen stimulation is unclear. Here we show that a TCF1CD127PD1 hepatitis C virus (HCV)-specific CD8 T-cell subset exists in chronically infected patients with phenotypic features of T-cell exhaustion and memory, both before and after treatment with direct acting antiviral (DAA) agents. This subset is maintained during, and for a long duration after, HCV elimination. After antigen re-challenge the less differentia...    »
 
Journal title abbreviation:
Nat Commun 
Year:
2017 
Journal volume:
Pages contribution:
15050 
Language:
eng 
TUM Institution:
Institut für Molekulare Immunologie