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Dokumenttyp:
journal article 
Autor(en):
Rietscher, René; Schröder, Matthias; Janke, Julia; Czaplewska, Justyna; Gottschaldt, Michael; Scherließ, Regina; Hanefeld, Andrea; Schubert, Ulrich S; Schneider, Marc; Knolle, Percy A; Lehr, Claus-Michael 
Titel:
Antigen delivery via hydrophilic PEG-b-PAGE-b-PLGA nanoparticles boosts vaccination induced T cell immunity. 
Abstract:
Here, we evaluate the use of hydrophilic PEG-b-PAGE-b-PLGA (PPP) for the preparation of antigen loaded nanoparticles (NPs) as a platform for prophylactic vaccination. To investigate the suitability of PPP-NPs for antigen delivery, we used the double emulsion evaporation technique to prepare NPs of different sizes, antigen-loading efficiencies and -release kinetics for the model antigen Ovalbumin (OVA). Prior to applying the PPP-NPs in biological in vitro or in vivo models, all materials were tes...    »
 
Zeitschriftentitel:
Eur J Pharm Biopharm 
Jahr:
2016 
Band / Volume:
102 
Seitenangaben Beitrag:
20-31 
Sprache:
eng 
Print-ISSN:
0939-6411 
TUM Einrichtung:
Institut für Molekulare Immunologie