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Dokumenttyp:
journal article 
Autor(en):
Chmielewski, Stefan; Olejnik, Adam; Sikorski, Krzysztof; Pelisek, Jaroslav; B?aszczyk, Katarzyna; Aoqui, Cristiane; Nowicka, Hanna; Zernecke, Alma; Heemann, Uwe; Wesoly, Joanna; Baumann, Marcus; Bluyssen, Hans A R 
Titel:
STAT1-dependent signal integration between IFN? and TLR4 in vascular cells reflect pro-atherogenic responses in human atherosclerosis. 
Abstract:
Signal integration between IFN? and TLRs in immune cells has been associated with the host defense against pathogens and injury, with a predominant role of STAT1. We hypothesize that STAT1-dependent transcriptional changes in vascular cells involved in cross-talk between IFN? and TLR4, reflect pro-atherogenic responses in human atherosclerosis. Genome-wide investigation identified a set of STAT1-dependent genes that were synergistically affected by interactions between IFN? and TLR4 in VSMCs. Th...    »
 
Zeitschriftentitel:
PLoS ONE 
Jahr:
2014 
Band / Volume:
Heft / Issue:
12 
Seitenangaben Beitrag:
e113318 
Sprache:
eng 
TUM Einrichtung:
Abteilung für Nephrologie; Klinik für Gefäßchirurgie