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- Titel:
Apolipoprotein E genotype, TNF-? 308G/A and risk for cardiac surgery associated-acute kidney injury in Caucasians.
- Dokumenttyp:
- Journal Article
- Autor(en):
- Boehm, Johannes; Eichhorn, Stefan; Kornek, Matthias; Hauner, Katharina; Prinzing, Anatol; Grammer, Joachim; Lahm, Harald; Wagenpfeil, Stefan; Lange, Ruediger
- Abstract:
- Acute kidney injury following cardiac surgery depicts a severe clinical problem that is strongly associated with adverse short- and long-term outcome. We analyzed two common genetic polymorphisms that have previously been linked to renal failure and inflammation, and have been supposed to be associated with cardiac surgery associated-acute kidney injury (CSA-AKI).A total of 1415 consecutive patients who underwent elective cardiac surgery with CPB at our institution were prospectively enrolled. Patients were genotyped for Apolipoprotein E (ApoE E2,E3,E4) (rs429358 and rs7412) and TNF-?-308 G > A (rs1800629).Demographic characteristics and procedural data revealed no significant differences between genotypes. No association between ApoE (E2,E3,E4) and TNF-?-308 G > A genotypes and the RIFLE criteria could be detected. Several multiple linear regression analyses for postoperative creatinine increase revealed highly significant associations for aortic cross clamp time (p < 0.001), CPB-time (p < 0.001), norepinephrine (p < 0.001), left ventricular function (p = 0.004) and blood transfusion (p < 0.001). No associations were found for ApoE (E2,E3,E4) and TNF-?-308 G > A genotypes or baseline creatinine. When the sample size is 1415, the multiple linear regression test of R(2 )= 0 for seven covariates assuming normal distribution will have at least 99% power with significance level 0.05 to detect an R(2) of 0.108 or 0.107 as observed in the data.ApoE (E2,E3,E4) polymorphism and the TNF-?-308 G > A polymorphism are not associated with renal injury after CPB.
- Zeitschriftentitel:
- Ren Fail
- Jahr:
- 2014
- Band / Volume:
- 36
- Heft / Issue:
- 2
- Seitenangaben Beitrag:
- 237-43
- Sprache:
- eng
- Volltext / DOI:
- doi:10.3109/0886022X.2013.835267
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/24059882
- Print-ISSN:
- 0886-022X
- TUM Einrichtung:
- Urologische Klinik und Poliklinik
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