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Document type:
journal article 
Author(s):
Menzel, MI; Farrell, EV; Janich, MA; Khegai, O; Wiesinger, F; Nekolla, S; Otto, AM; Haase, A; Schulte, RF; Schwaiger, M 
Title:
Multimodal assessment of in vivo metabolism with hyperpolarized [1-13C]MR spectroscopy and 18F-FDG PET imaging in hepatocellular carcinoma tumor-bearing rats. 
Abstract:
Abnormalities of tumor metabolism can be exploited for molecular imaging. PET imaging of (18)F-FDG is a well-established method using the avid glucose uptake of tumor cells. (13)C MR spectroscopic imaging (MRSI) of hyperpolarized [1-(13)C]pyruvate and its metabolites, meanwhile, represents a new method to study energy metabolism by visualizing, for example, the augmented lactate dehydrogenase activity in tumor cells. Because of rapid signal loss, this method underlies strict temporal limitations...    »
 
Journal title abbreviation:
J Nucl Med 
Year:
2013 
Journal volume:
54 
Journal issue:
Pages contribution:
1113-9 
Language:
eng 
Print-ISSN:
0161-5505 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik