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Document type:
journal article 
Author(s):
Neubert, Kirsten; Lehmann, Christian H K; Heger, Lukas; Baranska, Anna; Staedtler, Anna Maria; Buchholz, Veit R; Yamazaki, Sayuri; Heidkamp, Gordon F; Eissing, Nathalie; Zebroski, Henry; Nussenzweig, Michel C; Nimmerjahn, Falk; Dudziak, Diana 
Title:
Antigen delivery to CD11c+CD8- dendritic cells induces protective immune responses against experimental melanoma in mice in vivo. 
Abstract:
Dendritic cells (DCs) are central modulators of immune responses and, therefore, interesting target cells for the induction of antitumor immune responses. Ag delivery to select DC subpopulations via targeting Abs to DC inhibitory receptor 2 (DCIR2, clone 33D1) or to DEC205 was shown to direct Ags specifically to CD11c(+)CD8(-) or CD11c(+)CD8(+) DCs, respectively, in vivo. In contrast to the increasing knowledge about the induction of immune responses by efficiently cross-presenting CD11c(+)CD8(+...    »
 
Journal title abbreviation:
J Immunol 
Year:
2014 
Journal volume:
192 
Journal issue:
12 
Pages contribution:
5830-8 
Language:
eng 
Print-ISSN:
0022-1767 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene