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Document type:
journal article 
Author(s):
von Laffert, Maximilian; Warth, Arne; Penzel, Roland; Schirmacher, Peter; Kerr, Keith M; Elmberger, Göran; Schildhaus, Hans-Ulrich; Büttner, Reinhard; Lopez-Rios, Fernando; Reu, Simone; Kirchner, Thomas; Pauwels, Patrick; Specht, Katja; Drecoll, Enken; Höfler, Heinz; Aust, Daniela; Baretton, Gustavo; Bubendorf, Lukas; Stallmann, Sonja; Fisseler-Eckhoff, Annette; Soltermann, Alex; Tischler, Verena; Moch, Holger; Penault-Llorca, Frederique; Hager, Hendrik; Schäper, Frank; Lenze, Dido; Hummel, Mich...    »
 
Title:
Multicenter Immunohistochemical ALK-Testing of Non-Small-Cell Lung Cancer Shows High Concordance after Harmonization of Techniques and Interpretation Criteria. 
Abstract:
Detection of anaplastic lymphoma kinase (ALK)-gene rearrangements in non-small-cell lung cancer (NSCLC) is mainly performed by fluorescence in-situ hybridization (FISH). The question was raised if FISH might be replaced by immunohistochemistry (IHC) in a reliable and reproducible manner across different laboratories.After calibration of the staining instruments and training of the observers to binary interpretation (positive versus negative), 15 NSCLC were independently tested for ALK protein ex...    »
 
Journal title abbreviation:
J Thorac Oncol 
Year:
2014 
Journal volume:
Journal issue:
11 
Pages contribution:
1685-1692 
Language:
eng 
Print-ISSN:
1556-0864 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie