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Dokumenttyp:
journal article 
Autor(en):
Soehnlein, O; Drechsler, M; Döring, Y; Lievens, D; Hartwig, H; Kemmerich, K; Ortega-Gómez, A; Mandl, M; Vijayan, S; Projahn, D; Garlichs, CD; Koenen, RR; Hristov, M; Lutgens, E; Zernecke, A; Weber, C 
Titel:
Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes. 
Abstract:
We used a novel approach of cytostatically induced leucocyte depletion and subsequent reconstitution with leucocytes deprived of classical (inflammatory/Gr1(hi) ) or non-classical (resident/Gr1(lo) ) monocytes to dissect their differential role in atheroprogression under high-fat diet (HFD). Apolipoprotein E-deficient (Apoe(-/-) ) mice lacking classical but not non-classical monocytes displayed reduced lesion size and macrophage and apoptotic cell content. Conversely, HFD induced a selective exp...    »
 
Zeitschriftentitel:
EMBO Mol Med 
Jahr:
2013 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
471-81 
Sprache:
eng 
Print-ISSN:
1757-4676 
TUM Einrichtung:
Klinik für Gefäßchirurgie