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Document type:
journal article 
Author(s):
Su, Baowei; Cengizeroglu, Arzu; Farkasova, Katarina; Viola, Joana R; Anton, Martina; Ellwart, Joachim W; Haase, Rudolf; Wagner, Ernst; Ogris, Manfred 
Title:
Systemic TNF? gene therapy synergizes with liposomal doxorubicine in the treatment of metastatic cancer. 
Abstract:
Tumor necrosis factor alpha (TNF?) is a potent antitumoral cytokine, either killing tumor cells directly or affecting the tumor vasculature leading to enhanced accumulation of macromolecular drugs. Due to dose limiting side effects systemic administration of TNF? protein at therapeutically active doses is precluded. With gene vectors, tumor restricted TNF? expression can be achieved and in principle synergize with chemotherapy. Synthetic gene carriers based on polyamines were intravenously injec...    »
 
Journal title abbreviation:
Mol Ther 
Year:
2013 
Journal volume:
21 
Journal issue:
Pages contribution:
300-8 
Language:
eng 
Print-ISSN:
1525-0016 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung