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Document type:
journal article 
Author(s):
Grünwald, GK; Vetter, A; Klutz, K; Willhauck, MJ; Schwenk, N; Senekowitsch-Schmidtke, R; Schwaiger, M; Zach, C; Wagner, E; Göke, B; Holm, PS; Ogris, M; Spitzweg, C 
Title:
EGFR-Targeted Adenovirus Dendrimer Coating for Improved Systemic Delivery of the Theranostic NIS Gene. 
Abstract:
We recently demonstrated tumor-selective iodide uptake and therapeutic efficacy of combined radiovirotherapy after systemic delivery of the theranostic sodium iodide symporter (NIS) gene using a dendrimer-coated adenovirus. To further improve shielding and targeting we physically coated replication-selective adenoviruses carrying the hNIS gene with a conjugate consisting of cationic poly(amidoamine) (PAMAM) dendrimer linked to the peptidic, epidermal growth factor receptor (EGFR)-specific ligand...    »
 
Journal title abbreviation:
Mol Ther Nucleic Acids 
Year:
2013 
Journal volume:
Pages contribution:
e131 
Language:
eng 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik; Institut für experimentelle Onkologie und Therapieforschung