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Document type:
journal article 
Author(s):
Gorrini, Chiara; Baniasadi, Pegah S; Harris, Isaac S; Silvester, Jennifer; Inoue, Satoshi; Snow, Bryan; Joshi, Purna A; Wakeham, Andrew; Molyneux, Sam D; Martin, Bernard; Bouwman, Peter; Cescon, David W; Elia, Andrew J; Winterton-Perks, Zoe; Cruickshank, Jennifer; Brenner, Dirk; Tseng, Alan; Musgrave, Melinda; Berman, Hal K; Khokha, Rama; Jonkers, Jos; Mak, Tak W; Gauthier, Mona L 
Title:
BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival. 
Abstract:
Oxidative stress plays an important role in cancer development and treatment. Recent data implicate the tumor suppressor BRCA1 in regulating oxidative stress, but the molecular mechanism and the impact in BRCA1-associated tumorigenesis remain unclear. Here, we show that BRCA1 regulates Nrf2-dependent antioxidant signaling by physically interacting with Nrf2 and promoting its stability and activation. BRCA1-deficient mouse primary mammary epithelial cells show low expression of Nrf2-regulated ant...    »
 
Journal title abbreviation:
J Exp Med 
Year:
2013 
Journal volume:
210 
Journal issue:
Pages contribution:
1529-44 
Language:
eng 
Print-ISSN:
0022-1007 
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie