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Document type:
journal article 
Author(s):
del Fresno, Carlos; Soulat, Didier; Roth, Susanne; Blazek, Katrina; Udalova, Irina; Sancho, David; Ruland, Jürgen; Ardavín, Carlos 
Title:
Interferon-? production via Dectin-1-Syk-IRF5 signaling in dendritic cells is crucial for immunity to C. albicans. 
Abstract:
Type I interferon (IFN) is crucial during infection through its antiviral properties and by coordinating the immunocompetent cells involved in antiviral or antibacterial immunity. Type I IFN (IFN-? and IFN-?) is produced after virus or bacteria recognition by cytosolic receptors or membrane-bound TLR receptors following the activation of the transcription factors IRF3 or IRF7. IFN-? production after fungal infection was recently reported, although the underlying mechanism remains controversial....    »
 
Journal title abbreviation:
Immunity 
Year:
2013 
Journal volume:
38 
Journal issue:
Pages contribution:
1176-86 
Language:
eng 
Print-ISSN:
1074-7613 
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie