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Document type:
journal article 
Author(s):
Gaudet, Mia M; Kuchenbaecker, Karoline B; Vijai, Joseph; Klein, Robert J; Kirchhoff, Tomas; McGuffog, Lesley; Barrowdale, Daniel; Dunning, Alison M; Lee, Andrew; Dennis, Joe; Healey, Sue; Dicks, Ed; Soucy, Penny; Sinilnikova, Olga M; Pankratz, Vernon S; Wang, Xianshu; Eldridge, Ronald C; Tessier, Daniel C; Vincent, Daniel; Bacot, Francois; Hogervorst, Frans B L; Peock, Susan; Stoppa-Lyonnet, Dominique; KConFab Investigators; Peterlongo, Paolo; Schmutzler, Rita K; Nathanson, Katherine L; Piedmont...    »
 
Title:
Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk. 
Abstract:
Common genetic variants contribute to the observed variation in breast cancer risk for BRCA2 mutation carriers; those known to date have all been found through population-based genome-wide association studies (GWAS). To comprehensively identify breast cancer risk modifying loci for BRCA2 mutation carriers, we conducted a deep replication of an ongoing GWAS discovery study. Using the ranked P-values of the breast cancer associations with the imputed genotype of 1.4 M SNPs, 19,029 SNPs were selec...    »
 
Journal title abbreviation:
PLoS Genet 
Year:
2013 
Journal volume:
Journal issue:
Pages contribution:
e1003173 
Language:
eng 
Print-ISSN:
1553-7390 
TUM Institution:
Frauenklinik und Poliklinik