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Document type:
journal article 
Author(s):
Goldmann, T; Wieghofer, P; Müller, PF; Wolf, Y; Varol, D; Yona, S; Brendecke, SM; Kierdorf, K; Staszewski, O; Datta, M; Luedde, T; Heikenwalder, M; Jung, S; Prinz, M 
Title:
A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation. 
Abstract:
Microglia are brain macrophages and, as such, key immune-competent cells that can respond to environmental changes. Understanding the mechanisms of microglia-specific responses during pathologies is hence vital for reducing disease burden. The definition of microglial functions has so far been hampered by the lack of genetic in vivo approaches that allow discrimination of microglia from closely related peripheral macrophage populations in the body. Here we introduce a mouse experimental system t...    »
 
Journal title abbreviation:
Nat Neurosci 
Year:
2013 
Journal volume:
16 
Journal issue:
11 
Pages contribution:
1618-26 
Language:
eng 
Print-ISSN:
1097-6256 
TUM Institution:
Institut für Virologie