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Document type:
journal article 
Author(s):
Li, Kun; Fichna, Jakub; Schicho, Rudolf; Saur, Dieter; Bashashati, Mohammad; Mackie, Ken; Li, Yongyu; Zimmer, Andreas; Göke, Burkhard; Sharkey, Keith A; Storr, Martin 
Title:
A role for O-1602 and G protein-coupled receptor GPR55 in the control of colonic motility in mice. 
Abstract:
The G protein-coupled receptor 55 (GPR55) is a novel cannabinoid (CB) receptor, whose role in the gastrointestinal (GI) tract remains unknown. Here we studied the significance of GPR55 in the regulation of GI motility.GPR55 mRNA and protein expression were measured by RT-PCR and immunohistochemistry. The effects of the GPR55 agonist O-1602 and a selective antagonist cannabidiol (CBD) were studied in vitro and in vivo and compared to a non-selective cannabinoid receptor agonist WIN55,212-2. CB1/2...    »
 
Journal title abbreviation:
Neuropharmacology 
Year:
2013 
Journal volume:
71 
Pages contribution:
255-63 
Language:
eng 
Print-ISSN:
0028-3908 
TUM Institution:
II. Medizinische Klinik und Poliklinik