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- Document type:
- Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Article
- Author(s):
- Levine, SZ; Leucht, S
- Title:
- Early symptom response to antipsychotic medication as a marker of subsequent symptom change: an eighteen-month follow-up study of recent episode schizophrenia.
- Abstract:
- Differences between early- and delayed-responders to antipsychotic medication as a marker of subsequent symptom change to 18months are unknown.To examine the association between initial non-, early- and delayed-response and subsequent symptom change up to 18months in the antipsychotic treatment of the symptoms of recent-episode schizophrenia.Participants were from a double-blind randomized clinical trial of recent episode schizophrenia (n=263). Based on attainment of a 20% PANSS total change in the initial four weeks, the following groups were created and compared: "non-" (i.e., no-response): "early-" (i.e. within 2weeks) and "delayed-" (i.e. 3-4weeks) responders. Mixed modeling was used to predict PANSS percent change with group, time and the time-group interaction.Analysis of the PANSS total percent change showed significant (p<.01) group, time, and time-group interaction effects. Compared to non-responders, early-responders maintained significantly greater total response from week 5 to 44, and delayed-responders from week 5 to 20. After this time, non-responders and the other groups did not significantly differ on change. Generally, differences between the delayed- and early-responders were not statistically significance. Results were similar on the PANSS positive, negative and general psychopathology symptom subscales.Early-response is marked by up to 39weeks of longer subsequent symptom response than non-response, and infrequently differs to delayed-response. This has implications for consideration of switching and clinical trial design.
- Journal title abbreviation:
- Schizophr Res
- Year:
- 2012
- Journal volume:
- 141
- Journal issue:
- 2-3
- Pages contribution:
- 168-72
- Language:
- eng
- Fulltext / DOI:
- doi:10.1016/j.schres.2012.08.030
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/22995933
- Print-ISSN:
- 0920-9964
- TUM Institution:
- Klinik und Poliklinik für Psychiatrie und Psychotherapie
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