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Dokumenttyp:
journal article 
Autor(en):
Marozin, S; Altomonte, J; Apfel, S; Dinh, PX; De Toni, EN; Rizzani, A; Nüssler, A; Kato, N; Schmid, RM; Pattnaik, AK; Ebert, O 
Titel:
Posttranslational modification of vesicular stomatitis virus glycoprotein, but not JNK inhibition, is the antiviral mechanism of SP600125. 
Abstract:
Vesicular stomatitis virus (VSV), a negative-sense single-stranded-RNA rhabdovirus, is an extremely promising oncolytic agent for cancer treatment. Since oncolytic virotherapy is moving closer to clinical application, potentially synergistic combinations of oncolytic viruses and molecularly targeted antitumor agents are becoming a meaningful strategy for cancer treatment. Mitogen-activated protein kinase (MAPK) inhibitors have been shown to impair liver cell proliferation and tumor development,...    »
 
Zeitschriftentitel:
J Virol 
Jahr:
2012 
Band / Volume:
86 
Heft / Issue:
Seitenangaben Beitrag:
4844-55 
Sprache:
eng 
Print-ISSN:
0022-538X 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik; r Unfallchirurgie