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Document type:
journal article 
Author(s):
Singh, AK; Spiessberger, B; Zheng, W; Xiao, F; Lukowski, R; Wegener, JW; Weinmeister, P; Saur, D; Klein, S; Schemann, M; Krueger, D; Seidler, U; Hofmann, F 
Title:
Neuronal cGMP kinase I is essential for stimulation of duodenal bicarbonate secretion by luminal acid. 
Abstract:
Brief contact of the duodenal mucosa with luminal acid elicits a long-lasting bicarbonate (HCO(3)(-)) secretory response, which is believed to be the primary protective mechanism against mucosal damage. Here, we show that cGMP-dependent protein kinase type I-knockout (cGKI(-/-)) mice are unable to respond to a physiological H(+) stimulus with a HCO(3)(-) secretory response and spontaneously develop duodenal ulcerations. Smooth muscle-selective cGKI knock-in rescued the motility disturbance but n...    »
 
Journal title abbreviation:
FASEB J 
Year:
2012 
Journal volume:
26 
Journal issue:
Pages contribution:
1745-54 
Language:
eng 
Print-ISSN:
0892-6638 
TUM Institution:
r Pharmakologie und Toxikologie; II. Medizinische Klinik und Poliklinik