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- Document type:
- Journal Article
- Author(s):
- Jiao, L.; Bach, T.
- Title:
- Palladium-Catalyzed Direct 2-Alkylation of Indoles by Norbornene-Mediated Regioselective Cascade C-H Activation
- Abstract:
- A palladium-catalyzed direct 2-alkylation reaction of free N-H indoles has been developed. This reaction relies on a norbornene-mediated cascade C-H activation process at the indole ring, which features high regioselectivity and excellent functional group, tolerance. The reaction represents the first example for a generally applicable, direct C-H alkylation of indole at the 2-position.
- Congress title:
- ISI Document Delivery No.: 816IG Times Cited: 27 Cited Reference Count: 64 Jiao, Lei Bach, Thorsten Alexander von Humboldt foundation L.J. acknowledges support by the Alexander von Humboldt foundation. 27 Amer chemical soc Washington
- Journal title:
- Journal of the American Chemical Society
- Year:
- 2011
- Journal volume:
- 133
- Journal issue:
- 33
- Pages contribution:
- 12990-12993
- Fulltext / DOI:
- doi:10.1021/ja2055066
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