In the present work the cytotoxic effect of the substances Etoposid, Docetaxel and Imatinib (STI571) were examined on the cell lines PC3, LNCaP and DU145 using the XTT-Assay. Also the effect of radiotherapy with 5 Gy was object of these work. In addition, different setups combined the cytotoxic agents with radiotherapy on different days were evaluated. Both, the addition of the chemotherapeutic agents and radiotherapy with 5 Gy induced a significant inhibition of cell proliferation on the three cell lines. By the combination therapy it seems to be beneficial to begin with radiotherapy on day 1 and add the cytotoxic agent on day 3. In conclusion a regime with previous radiotherapy and following chemotherapy seems to be sensible.
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In the present work the cytotoxic effect of the substances Etoposid, Docetaxel and Imatinib (STI571) were examined on the cell lines PC3, LNCaP and DU145 using the XTT-Assay. Also the effect of radiotherapy with 5 Gy was object of these work. In addition, different setups combined the cytotoxic agents with radiotherapy on different days were evaluated. Both, the addition of the chemotherapeutic agents and radiotherapy with 5 Gy induced a significant inhibition of cell proliferation on the thre...
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