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Document type:
journal article 
Author(s):
Ghiglione, Y; Rodríguez, AM; De Candia, C; Carobene, M; Benaroch, P; Schindler, M; Salomón, H; Turk, G 
Title:
HIV-mediated up-regulation of invariant chain (CD74) correlates with generalized immune activation in HIV+ subjects. 
Abstract:
HIV Nef-mediated up-regulation of invariant chain (Ii chain, also CD74) is presumed to play an active role in HIV immunopathogenesis. However, this has not been definitely ascertained. In order to help elucidate this hypothesis, Ii chain, CD4, HLA-DR and HLA-ABC expression was analyzed ex vivo in monocyte-derived macrophages (MDMs) from HIV(+) subjects. Viral load, CD4(+) T cell count and immune activation were also determined in enrolled subjects. Correlations between these parameters and the m...    »
 
Journal title abbreviation:
Virus Res 
Year:
2012 
Journal volume:
163 
Journal issue:
Pages contribution:
380-4 
Language:
eng 
Print-ISSN:
0168-1702 
TUM Institution:
Institut für Virologie