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Document type:
journal article 
Author(s):
Nagel, J; Gross, B; Meggendorfer, M; Preiss, C; Grez, M; Brack-Werner, R; Dietzel, S 
Title:
Stably integrated and expressed retroviral sequences can influence nuclear location and chromatin condensation of the integration locus. 
Abstract:
The large-scale chromatin organization of retrovirus and retroviral gene vector integration loci has attracted little attention so far. We compared the nuclear organization of transcribed integration loci with the corresponding loci on the homologous chromosomes. Loci containing gamma-retroviral gene transfer vectors in mouse hematopoietic precursor cells showed small but significant repositioning of the integration loci towards the nuclear interior. HIV integration loci in human cells showed a...    »
 
Journal title abbreviation:
Chromosoma 
Year:
2012 
Journal volume:
121 
Journal issue:
Pages contribution:
353-67 
Language:
eng 
Print-ISSN:
0009-5915 
TUM Institution:
Institut für Virologie