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- Document type:
- Journal Article; Research Support, Non-U.S. Gov't; Article
- Author(s):
- Stamelou, M; Christ, H; Reuss, A; Oertel, W; Höglinger, G
- Title:
- Hypodipsia discriminates progressive supranuclear palsy from other parkinsonian syndromes.
- Abstract:
- The objective of this study was to evaluate whether the sensation of thirst differs between patients with progressive supranuclear palsy (PSP), multiple system atrophy with predominant parkinsonism (MSA-P), and Parkinson's disease (PD).We administered a standardized thirst questionnaire to age-, sex-, and stage-matched patients with probable PSP, PD, and MSA-P and healthy controls (HC), n = 15/group. In an independent cohort (n = 10/group), we provoked thirst by infusing hypertonic NaCl in age-, sex-, and stage-matched patients with PSP, PD, and MSA-P and recorded plasma osmolality and thirst (visual analog scale).On questioning, 73% of PSP patients reported a reduced sensation of thirst (hypodipsia) compared with previous years (HC, 0%; PD, 7%; MSA-P, 7%; P < .0001). On NaCl infusion, PSP patients reported significantly lower thirst than did PD and MSA-P patients for all times from 20 to 95 minutes (P < .05). The thirst score at 25 minutes discriminated individual PSP patients well from PD and MSA-P patients.Hypodipsia appears helpful in differentiating PSP from PD and MSA-P.
- Journal title abbreviation:
- Mov Disord
- Year:
- 2011
- Journal volume:
- 26
- Journal issue:
- 5
- Pages contribution:
- 901-5
- Language:
- eng
- Fulltext / DOI:
- doi:10.1002/mds.23587
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/21384428
- Print-ISSN:
- 0885-3185
- TUM Institution:
- Neurologische Klinik und Poliklinik
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