Benutzer: Gast  Login
Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Brandl, M; Seidler, B; Haller, F; Adamski, J; Schmid, RM; Saur, D; Schneider, G
Titel:
IKK(?) controls canonical TGF(ß)-SMAD signaling to regulate genes expressing SNAIL and SLUG during EMT in panc1 cells.
Abstract:
The epithelial to mesenchymal transition (EMT) is a crucial step in tumor progression, and the TGF?-SMAD signaling pathway is an inductor of EMT in many tumor types. One hallmark of EMT is downregulation of the adherens junction protein E-cadherin, a process mediated by transcription factors such as the zinc fingers SNAIL and SLUG. Here, we report that the catalytic I?B kinase (IKK) subunit IKK? is necessary for the silencing of E-cadherin in a Panc1 cell model of TGF?-SMAD-mediated EMT, indepen...     »
Zeitschriftentitel:
J Cell Sci
Jahr:
2010
Band / Volume:
123
Heft / Issue:
Pt 24
Seitenangaben Beitrag:
4231-9
Sprache:
eng
Volltext / DOI:
doi:10.1242/jcs.071100
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21081648
Print-ISSN:
0021-9533
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
 BibTeX