Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis.

Dokumenttyp:: Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):: Nischwitz, S; Cepok, S; Kroner, A; Wolf, C; Knop, M; Muller-Sarnowski, F; Pfister, H; Roeske, D; Rieckmann, P; Hemmer, B; Ising, M; Uhr, M; Bettecken, T; Holsboer, F; Müller-Myhsok, B; Weber, F
Titel:: Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis.
Abstract:: In a genome wide association study consisting of 592 German multiple sclerosis (MS) patients and 825 controls we were able to replicate the association of the HLA region with MS independently of previous case control studies. No SNPs outside the HLA region reached a genome wide level of significance. Nevertheless, we found suggestive evidence for an association of MS with variants in two new genes, the VAV2 gene and the gene for ZNF433.
Zeitschriftentitel:: J Neuroimmunol
Jahr:: 2010
Band / Volume:: 227
Heft / Issue:: 1-2
Seitenangaben Beitrag:: 162-6
Sprache:: eng
Volltext / DOI:: doi:10.1016/j.jneuroim.2010.06.003
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/20598377
Print-ISSN:: 0165-5728
TUM Einrichtung:: Neurologische Klinik und Poliklinik
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