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Document type:
journal article 
Author(s):
Füchtemeier, M; Leithner, C; Offenhauser, N; Foddis, M; Kohl-Bareis, M; Dirnagl, U; Lindauer, U; Royl, G 
Title:
Elevating intracranial pressure reverses the decrease in deoxygenated hemoglobin and abolishes the post-stimulus overshoot upon somatosensory activation in rats. 
Abstract:
BOLD fMRI localizes activated brain areas by measuring decreases of deoxygenated hemoglobin (deoxy-Hb) caused by neurovascular coupling. To date, it is unclear whether intracranial pressure (ICP) modifies deoxy-Hb signaling for brain mapping. In addition, ICP elevation can test whether the BOLD post-stimulus undershoot, a transient hypo-oxygenation following functional activation, is due to vascular compliance rather than elevated cerebral metabolic rate of oxygen (CMRO(2)). We addressed these q...    »
 
Journal title abbreviation:
Neuroimage 
Year:
2010 
Journal volume:
52 
Journal issue:
Pages contribution:
445-54 
Language:
eng 
Print-ISSN:
1053-8119 
TUM Institution:
Neurochirurgische Klinik und Poliklinik