Right ventricular function in grown-up patients after correction of congenital right heart disease.

Lemmer, J; Heise, G; Rentzsch, A; Boettler, P; Kuehne, T; Dubowy, KO; Peters, B; Lemmer, B; Hager, A; Stiller, B

doi:10.1007/s00392-010-0241-8

journal article

Document type:: Journal Article
Author(s):: Lemmer, J; Heise, G; Rentzsch, A; Boettler, P; Kuehne, T; Dubowy, KO; Peters, B; Lemmer, B; Hager, A; Stiller, B
Title:: Right ventricular function in grown-up patients after correction of congenital right heart disease.
Abstract:: AIMS: We investigated whether a correlation exists between biomarkers of the neurohumoral system and clinical markers in grown-up patients with congenital heart disease (GUCH) and right ventricular function. METHODS AND RESULTS: Prospective, cross-sectional, multicenter study of 104 GUCH patients (median) 16 years (range 6-43 years) after corrective surgery with RV pressure and/or volume overload and 54 healthy controls. Clinical, functional, and laboratory parameters were assessed. Natriuretic peptide levels were significantly increased in GUCH patients (NTproBNP 101 vs. 25 pg/ml, p < 0.001), but we observed no differences in norepinephrine, aldosterone, angiotensin II and Endothelin-1 levels. NTproBNP correlated significantly with clinical markers such as NYHA classification, prolonged QRS duration and reduced exercise capacity (VO(2) peak) (all p < 0.001), as well as self-reported quality of life (p < 0.001). MRI and echocardiography derived RV volumes were elevated and ejection fraction reduced in the patients (both p < 0.001). Tissue Doppler parameter showed significantly restricted ventricular longitudinal systolic function (longitudinal tricuspid valve movement, 1.7 vs. 2.3 cm, p < 0.001), suggesting stiffness and reduced RV compliance. CONCLUSION: In conclusion, grown-up patients with congenital right heart disease NTproBNP correlates well with various clinical markers of RV failure, such as prolongation of QRS duration, exercise capacity, echocardiography and MRI parameters, and quality of life.
Journal title abbreviation:: Clin Res Cardiol
Year:: 2011
Journal volume:: 100
Journal issue:: 4
Pages contribution:: 289-296
Language:: eng
Fulltext / DOI:: doi:10.1007/s00392-010-0241-8
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/20981430
Print-ISSN:: 1861-0684
TUM Institution:: Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Lehr- und Forschungskooperationen mit den Kliniken und Instituten am Deutschen Herzzentrum Klinik für Kinderkardiologie und angeborene Herzfehler (DHM) (Prof. Ewert)2011