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Document type:
journal article 
Author(s):
Schüler, S; Diersch, S; Hamacher, R; Schmid, RM; Saur, D; Schneider, G 
Title:
SKP2 confers resistance of pancreatic cancer cells towards TRAIL-induced apoptosis. 
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dismal prognosis and no effective conservative therapy exists. Although the F-box protein S-phase kinase associated protein 2 (SKP2) is highly expressed and regulates cell cycle progression in PDAC, alternative SKP2 functions in PDAC are unknown. Using RNA interference we now demonstrate that SKP2 confers resistance of a subset of PDAC cell lines towards the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), but not the...    »
 
Journal title abbreviation:
Int J Oncol 
Year:
2011 
Journal volume:
38 
Journal issue:
Pages contribution:
219-25 
Language:
eng 
Print-ISSN:
1019-6439 
TUM Institution:
II. Medizinische Klinik und Poliklinik