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Document type:
Journal Article 
Author(s):
Wa?ngler, C; Waser, B; Alke, A; Iovkova, L; Buchholz, HG; Niedermoser, S; Jurkschat, K; Fottner, C; Bartenstein, P; Schirrmacher, R; Reubi, JC; Wester, HJ; Wa?ngler, B 
Title:
One-Step (18)F-Labeling of Carbohydrate-Conjugated Octreotate-Derivatives Containing a Silicon-Fluoride-Acceptor (SiFA): In Vitro and in Vivo Evaluation as Tumor Imaging Agents for Positron Emission Tomography (PET). 
Abstract:
The synthesis, radiolabeling, and initial evaluation of new silicon-fluoride acceptor (SiFA) derivatized octreotate derivatives is reported. So far, the main drawback of the SiFA technology for the synthesis of PET-radiotracers is the high lipophilicity of the resulting radiopharmaceutical. Consequently, we synthesized new SiFA-octreotate analogues derivatized with Fmoc-NH-PEG-COOH, Fmoc-Asn(Ac(3)AcNH-?-Glc)-OH, and SiFA-aldehyde (SIFA-A). The substances could be labeled in high yields (38 ± 4%)...    »
 
Journal title abbreviation:
Bioconjug Chem 
Year:
2010 
Journal volume:
21 
Journal issue:
12 
Pages contribution:
2289-2296 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
1043-1802 
TUM Institution:
Klinik und Poliklinik für Nuklearmedizin