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Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Faensen, B; Wildemann, B; Hain, C; Höhne, J; Funke, Y; Plank, C; Stemberger, A; Schmidmaier, G 
Title:
Local application of BMP-2 specific plasmids in fibrin glue does not promote implant fixation. 
Abstract:
BMP-2 is known to accelerate fracture healing and might also enhance osseointegration and implant fixation. Application of recombinant BMP-2 has a time-limited effect. Therefore, a gene transfer approach with a steady production of BMP-2 appears to be attractive. The aim of this study was to examine the effect of locally applied BMP-2 plasmids on the bone-implant integration in a non-weight bearing rabbit tibia model using a comparatively new non-viral copolymer-protected gene vector (COPROG).Si...    »
 
Journal title abbreviation:
BMC Musculoskelet Disord 
Year:
2011 
Journal volume:
12 
Pages contribution:
163 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
1471-2474 
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung