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Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Klier, J; May, A; Fuchs, S; Schillinger, U; Plank, C; Winter, G; Gehlen, H; Coester, C 
Title:
Immunostimulation of bronchoalveolar lavage cells from recurrent airway obstruction-affected horses by different CpG-classes bound to gelatin nanoparticles. 
Abstract:
Recurrent airway obstruction (RAO) in horses has become a common problem in stabled horses in industrialized countries and deserves new therapeutic strategies. CpG-oligodeoxynucleotides (CpG-ODNs) were developed as effective immunostimulating agents to induce a Th2/Th1 shift. These agents showed a beneficial therapeutic effect in allergic diseases with predominant Th2 immunoresponse. CpG-ODN delivery by gelatin nanoparticles (GNPs) resulted in enhanced cellular uptake in murine and human in vitr...    »
 
Journal title abbreviation:
Vet Immunol Immunopathol 
Year:
2011 
Journal volume:
144 
Journal issue:
1-2 
Pages contribution:
79-87 
Language:
eng 
Print-ISSN:
0165-2427 
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung