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- Original title:
- Untersuchung von Strukturfunktionsbeziehungen bei Enzymen der Tetrahydrobiopterin- und Riboflavinbiosynthese
- Translated title:
- Function and structure analysis of enzymes involved in tetrahydrobiopterin and riboflavin biosynthesis
- Author:
- Schiffmann, Susanne
- Year:
- 2002
- Document type:
- Dissertation
- Faculty/School:
- Fakultät für Chemie
- Advisor:
- Bacher, Adelbert (Prof. Dr. Dr.)
- Referee:
- Gierl, Alfons (Prof. Dr.)
- Format:
- Text
- Language:
- de
- Subject group:
- CHE Chemie
- Keywords:
- Riboflavin; Tetrahydrobiopterin; Kinetik; Struktur; 3; 4-Dihydroxy-2-butanon-4-phosphat Synthase; GTP Cyclohydrolase I Feedbackregulatorprotein; GTP Cyclohydrolase I
- Translated keywords:
- riboflavin; tetrahydrobiopterin; kinetic; structure; GTP cyclohydrolase I feedbackregulatory protein; GTP cyclohydrolase I; 3; 4-dihydroxy-2-butanone-4-phosphate synthase
- Controlled terms:
- Synthasen; Methanocaldococcus jannaschii; Struktur-Aktivitäts-Beziehung; GTP-Cyclohydrolase; Transkriptionsfaktor; Tetrahydrobiopterin; Biosynthese; Vitamin B2
- TUM classification:
- CHE 806d; CHE 827d; CHE 829d; CHE 832d
- Abstract:
- Arbeiten im Rahmen der Dissertation ermöglichten die Aufklärung der räumlichen Struktur der 3,4-Dihydroxy-2-butanon-4-phosphat Synthase aus M. jannaschii. Durch kinetische Experimente mit mutierten Proteinen konnte einzelnen Aminosäuren des aktiven Zentrums Funktionen bei der Katalyse zugewiesen werden. Die molekularbiologischen und biochemischen Vorarbeiten ermöglichten die Lösung der dreidimensionalen Struktur des GTP Cyclohydrolase I Feedbackregulatorproteins (GFRP). Durch kinetische Studien... »
- Translated abstract:
- The three-dimensional structure of 3,4-dihydroxy-2-butanone-4-phosphate synthase from M. jannaschii with its natural substrate ribulose-5-phosphate has been determined. By Kinetic characterisation of mutant proteins some amino acids located at the active site could be assigned to special functions in catalysis. The three-dimensional structure of GTP Cyclohydrolase I feedback regulatory protein from rat has been solved. Kinetical experiments with the GTP cyclohydrolase I/GTP cyclohydrolase I feed... »
- Publication :
- Universitätsbibliothek der TU München
- WWW:
- https://mediatum.ub.tum.de/?id=601250
- Date of submission:
- 30.04.2002
- Oral examination:
- 03.07.2002
- File size:
- 1685622 bytes
- Pages:
- 142
- Urn (citeable URL):
- https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss2002070307295
- Last change:
- 11.06.2007
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